2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Ser/Thr Protease

Ser/Thr Protease

Serine proteases; Serine endopeptidases; Threonine proteases

Ser/Thr Protease

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Serine (Ser) proteases catalyse the hydrolysis of specific peptide bonds in their substrates and this activity depends on a set of amino acids in the active site of the enzyme, one of which is always a serine. There are two families especially well studied, the trypsin family and the subtilisin family. Serine proteases play crucial roles in a wide variety of cellular as well as extracellular functions, including the process of blood clotting, protein digestion, cell signaling, inflammation, and protein processing. Threonine (Thr) proteases are a family of proteolytic enzymes harbouring a threonine residue within the active site. The prototype members of this class of enzymes are the catalytic subunits of the proteasome, however the acyltransferases convergently evolved the same active site geometry and mechanism.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-149926
    Cathepsin Inhibitor 3
    Cathepsin Inhibitor 3 (Compound 53k) is a non-radioactive intermediate in compound [18F] 2k radioactive synthesis, which has selectivity for cathepsin S. Cathepsin Inhibitor 3 can undergo radioactive fluorination and can be used for fluorine-18 labeling research. Cathepsin Inhibitor 3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Cathepsin Inhibitor 3
  • HY-P991137
    Exerenibart
    		Inhibitor
    Exerenibart is an immunoglobulin G4-κ monoclonal antibody targeting human transmembrane serine protease 6 (TMPRSS6). Exerenibart is promising for research of diseases associated with iron metabolism disorders, such as iron overload or iron deficiency.
    Exerenibart
  • HY-N4330
    Rivulariapeptolides 1155
    		Inhibitor
    Rivulariapeptolides 1155 is a potent serine protease inhibitor with IC50s of 41.84, 4.94, 56.54 nM for chymotrypsin, elastase, prpteinase K, respectively.
    Rivulariapeptolides 1155
  • HY-163185
    DCLK1-IN-4
    		Inhibitor
    DCLK1-IN-4 (compound D2) is a potent and selective doublecortin-like kinase 1 (DCLK1) inhibitor with an IC50 of 70 nM. DCLK1-IN-4 can be used for the research of cancer.
    DCLK1-IN-4
  • HY-134432A
    Boc-Gln-Ala-Arg-AMC hydrochloride
    Boc-Gln-Ala-Arg-AMC hydrochloride is a fluorogenic substrate for trypsin. Boc-Gln-Ala-Arg-AMC hydrochloride can also be used for measuring the proteolytic activity of TMPRSS2.
    Boc-Gln-Ala-Arg-AMC hydrochloride
  • HY-P0133
    (Arg) 9
    		Inhibitor
    (Arg)9 (Nona-L-arginine) is a cell-penetrating peptide (CPP) made up of 9 arginine residues, which is an inhibitor of serine endoprotease Furin. (Arg)9 has neuroprotective property, exhibits neuroprotective activity with an IC50 of 0.78 μM in the glutamic acid model.
    (Arg) 9
  • HY-126980
    AMG-126737
    		Inhibitor
    AMG-126737 is an orally active and highly selective human mast cell tryptase inhibitor with a Ki of 90 nM. AMG-126737 suppresses early/late-phase bronchoconstriction in sheep models. AMG-126737 is promising for research of asthma and allergic diseases.
    AMG-126737
  • HY-147278C
    Manusiran sodium scrambled negative control
    		Inhibitor
    Manusiran sodium scrambled negative control is the sequence scrambled negative control of Manusiran sodium.
    Manusiran sodium scrambled negative control
  • HY-161902
    MI-1904
    		Inhibitor
    MI-1904 is the inhibitor for matriptase/TMPRSS2, that exhibits antiviral activity against influenza virus H1N1 and H9N2. MI-1904 blocks the cleavage of glycoproteins on the viral surface, prevents the virus from binding to host cell receptors, and thus inhibits the entry and replication of the virus.
    MI-1904
  • HY-P4254
    H-Gly-Glu-pNA
    		Substrate
    H-Gly-Glu-pNA is a chromogenic peptide substrate that can be widely used in enzymatic analysis, including trypsin and urokinase-type plasminogen activator (uPA).
    H-Gly-Glu-pNA
  • HY-N4332
    Rivulariapeptolides 1121
    		Inhibitor
    Rivulariapeptolides 1121 is a high potent and selective serine protease inhibitor with IC50 values of 35.52 nM, 13.24 nM and 48.05 nM for chymotrypsin, elastase and proteinase K, respectively.
    Rivulariapeptolides 1121
  • HY-152150
    Thrombin inhibitor 7
    		Inhibitor
    Thrombin inhibitor 7 is a potent FXIIa inhibitor with IC50 values of 28 nM, >132 µM for FXIIa and FXIa, respectively. Thrombin inhibitor 7 shows low cytotoxicity.
    Thrombin inhibitor 7
  • HY-181764
    LZL50
    		Activator
    LZL50 is an orally effective human caseinolytic protease P (hClpP) activator with an EC50 of 0.29 μM. LZL50 activates hClpP, a serine protease that mediates mitochondrial quality control by degrading damaged or misfolded mitochondrial proteins. LZL50 exhibits antitumor activity in a breast cancer xenograft mouse model. LZL50 can be used in research related to breast cancer.
    LZL50
  • HY-117291
    XMD-17-51
    		Inhibitor
    XMD-17-51 is a pyrimido-diazepinone compound that is able to modulate protein kinases.
    XMD-17-51
  • HY-137495A
    GGACK hydrochloride
    		Inhibitor
    GGACK (H-Glu-Gly-Arg-CMK) hydrochloride is an irreversible substrate-like serine protease urokinase-type plasminogen activator (uPA) inhibitor.
    GGACK hydrochloride
  • HY-184117
    pMeO-Bz-SF
    		Inhibitor
    pMeO-Bz-SF is a covalent, stereoselective α-chymotrypsin inhibitor with an IC50 value of 133 nM. The (R)-enantiomer of pMeO-Bz-SF inhibits α-chymotrypsin with an IC50 of 101 nM. The (S)-enantiomer of pMeO-Bz-SF shows low activity against α-chymotrypsin, with an IC50 of 2965 nM.
    pMeO-Bz-SF
  • HY-P11413
    PAI-1
    PAI-1 is a plasminogen activator inhibitor. PAI-1 is a member of the Ser Protease inhibitor superfamily with antiprotease activity. PAI-1 is the main physiological inhibitor of tissue-type (tPA) and urokinase-type (uPA) plasminogen activators (PAs).
    PAI-1
  • HY-114164E
    Rabbit Thrombin
    Rabbit Thrombin is a serine protease. Rabbit Thrombin forms a covalent complex with antithrombin III and reversibly binds endothelial cell surface high-affinity sites. Rabbit Thrombin regulates VEGF and Ang-2, potentiates VEGF mitogenic activity and protects endothelial cells from apoptosis. Rabbit Thrombin can be used for the research of hindlimb ischemia.
    Rabbit Thrombin
  • HY-E70228
    Cathepsin H, human liver
    Cathepsin H, human liver is an aminopeptidase and an endopeptidase. Involved in the catabolism of proteins in the lysosomal system. Cathepsin H, human liver has a key role in the regulation of the biological behavior of tumor cells and the pathological processes of brain diseases.
    Cathepsin H, human liver
  • HY-171129
    EP055
    EP055 is a non-hormonal male contraceptive. EP055 targets to sperm protein EPPIN and inhibits anti-EPPIN antibodies from binding EPPIN with an IC50 of 1121 μM. EP055 can inhibit sperm motility (IC50 = 199.5 μM) by reducing the internal pH and Ca2+ levels of the sperm, thereby causing the sperm to aggregate. EP055 can be used for development of male contraceptive.
    EP055
Cat. No. Product Name / Synonyms Application Reactivity